Blame It on Madame MacEvil

How appropriate that in her first appearance Moondragon referred to herself as Madame MacEvil (Iron Man #54). She was one of numerous Defenders who made their debut as villains. Hidden in an undersea vessel, Madame MacEvil used advanced technology to seize control of Iron Man's armor, forcing him to battle Sub-Mariner. With half-human, half-Atlantean physiology, Prince Namor would make the ideal scientific specimen for Madame MacEvil—if she could compel Iron Man to defeat him. But Iron Man's mind was still intact, and he tried to explain that he wasn't in control of his actions while attacking Namor. Considering how often they had battled over the years, it's little surprise that the Prince of Atlantis wasn't convinced. While secretly observing the fight, Madame MacEvil squabbled with her ship's computer. She and the machine took turns throwing insults back and forth, calling each other too cold or too emotional. Iron Man eventually regained control of his armor and flew off, leaving the Prince of Atlantis understandably confused. At the end of the issue, neither of them knew that Madam MacEvil had orchestrated the dispute.

Iron Man. Vol. 1. No. 54. January 1973. "Sub-Mariner: Target for Death!" Mike Friedrich (script), George Tuska (pencils), Vinnie Colletta (inks), Artie Simek (lettering), Roy Thomas (editing), Story idea & helping hand from: Bill Everett.